| ncRNA name | P2RX7-V3 |
| ncRNA Category | lncRNA |
| ID | 101103842 |
| Ensembl | ENSOARG00000015479 |
| Synonyms | MGC20089, P2X7 |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | UM cell lines MUM2B and OM431; human embryonic kidney cell line HEK293T |
| Methods | qRT-PCR, xenograft, immunohistochemistry, microarray |
| Expression pattern | up-regulated |
| Functional description | We identified a transcriptional variant transcribed from the P2RX7 gene locus, named P2RX7-V3 (P2RX7 variant 3), which was expressed at a high level in UM cells. P2RX7-V3 silencing revealed that this variant acts as a necessary UM oncoRNA. Knockdown of P2RX7-V3 expression significantly suppressed tumor growth in vitro and in vivo. |
| PubMed ID | 27468714 |
| Year | 2016 |
| Title | P2RX7-V3 is a novel oncogene that promotes tumorigenesis in uveal melanoma. |
| Drug-related ncRNA | NO |
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